Skin Cancer da UVB Phototherapy

Menene haɗarin ciwon daji na fata tare da UVB phototherapy?

Ba kamar hasken ultraviolet daga hasken rana na halitta da fitulun tanning na kwaskwarima, yawancin shekarun da aka yi amfani da su a cikin dermatology sun nuna cewa UVB/UVB-Narrowband phototherapy (wanda ke da UVA sosai cire) ba babban haɗari bane ga kansar fata;
ciki har da basal cell carcinoma (BCC), squamous cell carcinoma (SCC) da kuma cutar m melanoma (CMM).

Don tallafawa wannan sanarwa, da fatan za a yi la'akari
abubuwan binciken da suka biyo baya, da tattaunawar da ta biyo baya:

Wani binciken da aka buga a watan Disamba 2023 da ake kira
Abubuwan da suka faru da bayanin martaba na cututtukan fata a cikin marasa lafiya da ke bin ultraviolet phototherapy ba tare da psoralens sun ƙare ba:

 

 

"A cikin duka, marasa lafiya 3506 da aka bi da su tare da broadband-ultraviolet-B, narrowband-UVB da / ko hade UVAB an kimanta su tare da ma'anar biye da shekaru 7.3 da aka kammala cewa babu ƙarin haɗarin melanoma kuma an sami ciwon daji na keratinocyte tare da phototherapy"

Wani sabon bincike mai ban sha'awa da aka buga a Afrilu 2023 ya nuna "Mutanen da ke da vitiligo suna da ƙananan haɗari na melanoma da kuma wadanda ba melanoma ba idan aka kwatanta da yawan jama'a."
Ya kuma bayyana cewa "Bisa damuwa da cewa wasu jiyya na vitiligo, irin su tsawan lokaci phototherapy, na iya ƙara haɗarin ciwon daji na fata, raguwar raguwar cutar kansar fata ya kamata ya zama mai kwantar da hankali ga duka mutanen da ke da vitiligo da likitocin da ke kula da yanayin."

A sabon binciken da aka buga a watan Agusta 2022 daga Vancouver (Halayen ciwon daji na fata a cikin marasa lafiya tare da eczema da aka bi da su tare da ultraviolet phototherapy) ya kammala cewa:

 

Gabaɗaya, ban da marasa lafiya waɗanda ke da tarihin shan maganin rigakafi, babu ƙarin haɗarin melanoma, squamous cell carcinoma, ko carcinoma basal cell a cikin marasa lafiya waɗanda ke karɓar ultraviolet phototherapy, gami da narrowband UVB, broadband UVB, da UVA tare da broadband. UVB, yana goyan bayan wannan azaman magani mara cutar kansa ga marasa lafiya tare da eczema.

"Bincike na karatu akan UVB, duka kunkuntar da kuma broadband, ba su nuna wani ƙarin haɗarin ciwon daji na fata ba ko melanoma."

Don karanta cikakken binciken, bi wannan hanyar haɗi:

Jiyya don psoriasis da haɗarin malignancy.

Patel RV1, Clark LN, Lebwohl M, Weinberg JM.

"A cikin wannan babban binciken, tare da bin diddigin har zuwa shekaru 22 daga farkon jiyya tare da NB-UVB, ba mu sami wata takamaiman alaƙa tsakanin jiyya na NB-UVB da BCC, SCC ko ciwon fata na melanoma ba." 

Don karanta cikakken binciken, bi wannan hanyar haɗi:
Abubuwan da suka faru na ciwon daji na fata a cikin marasa lafiya 3867 da aka bi da su tare da Narrow-Band UVB Phototherapy
Saurari RMKarar ACRahim KFFerguson JDaga RS.

"Ba a sami ƙarin haɗarin kamuwa da cutar kansar fata ba a cikin binciken huɗun da ke tantance yiwuwar haɗarin cutar kansa na NB-UVB."

Don karanta cikakken binciken, bi wannan hanyar haɗi:
Haɗarin Carcinogenic na psoralen UV-A far da kunkuntar UV-B far a cikin psoriasis plaque na kullum: nazari na wallafe-wallafe.

Archier E1, Devaux S, Castela E, Gallini A, Aubin F, Le Maître M, Aractingi S, Bachelez H.

"Babu wani bambance-bambance masu mahimmanci tsakanin nbUVB da kungiyoyin sarrafawa. Don haka, nbUVB phototherapy ta amfani da fitilun TL-01 da alama ya zama ingantaccen tsarin warkewa ga marasa lafiya da ke da hoton fata na III-V.

Don karanta cikakken binciken, bi wannan hanyar haɗi:
Babu wata shaida don ƙara haɗarin kansar fata a cikin Koreans tare da hoton fata na III-V da aka yi da ƙuƙumman UVB phototherapy.

Jo SJ1, Kwon HH, Choi MR, Youn JI.

“Dr. Lebwohl ya ce. "Aƙalla ya zuwa yanzu, ya bayyana cewa UVB narrowband baya taimakawa ga ciwon daji na fata. Duk da haka, a cikin marasa lafiya da ke fama da ciwon daji, muna yin taka tsantsan game da amfani da phototherapy. "

Don karanta cikakken binciken, bi wannan hanyar haɗi:
Magungunan psoriasis na kowa
tasiri chances na majiyyata suna tasowa ciwon fata Dematology Times May-2017

"Don haka, binciken na yanzu baya ba da shaida don ƙara haɗarin ciwon daji na fata ga marasa lafiya da aka yi musu magani tare da watsawa ko kunkuntar UVB phototherapy." 


Don karanta cikakken binciken, bi wannan hanyar haɗi:
Babu wata shaida don ƙara haɗarin ciwon daji na fata a cikin marasa lafiya na psoriasis da aka bi da su tare da watsa shirye-shiryen watsa shirye-shirye ko UVB phototherapy narrowband: nazari na farko na baya.

Weischer M1, Blum A, Eberhard F, Röcken M, Berneburg M.

“(UVB-Narrowband) Phototherapy yana da aminci kuma mai sauƙin aiwatarwa. Ko da yake rikitarwa na iya haɗawa da kunar rana, ba mu ganin kowane ciwon daji na fata, melanoma ko wadanda ba melanoma ba. Vitiligo tabbas yana da kariya ga melanoma. 

Sabbin tunani, hanyoyin kwantar da hankali don vitiligo - Pearl Grimes - Labarin cututtukan fata Aug-2016

"Duk da damuwa game da yuwuwar cutar carcinogenic na radiation ultraviolet, yawancin binciken ba su sami ƙarin haɗarin marasa lafiya na melanoma ko cutar kansar fata ba a cikin marasa lafiya da aka bi da su tare da ultraviolet B (broadband da narrowband) da ultraviolet A1 phototherapy."

Don karanta cikakken binciken, bi wannan hanyar haɗi:
Gefen duhu na haske: Phototherapy mummunan sakamako.

Valejo Coelho MM1, Apetato M2.

tattaunawa

Ultraviolet radiation (UVR) daga hasken rana na halitta
"ana daukarsa a matsayin babban abin da ke haddasawa
a shigar da cutar kansar fata”

An raba UVR zuwa:

UVA
320-400nm
Tsayin tanning

UVB
280-320nm
The kona wavelengths

UVC
100-280nm
Tace da yanayin duniya

Farashin UVB
Don haka, don dalilan wannan tattaunawa, UVR=UVA+UVB.

Kowane tsayin haske daban-daban yana haifar da nau'ikan tasirin halitta iri-iri a cikin fatar ɗan adam. Tsawon tsayin daka na UVA yana shiga cikin dermis, yayin da UVB ke shiga cikin epidermis kawai.

Akwai manyan nau'ikan ciwon daji na fata guda uku:

BCC

carcinoma basal cell

CSC

ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar cuta

CMM

melanoma na fata

BCC da SCC an haɗa su tare azaman cututtukan fata waɗanda ba melanoma ba (NMSC), kuma sun dogara da adadin tsawon rayuwa na UVB. Wuraren fata waɗanda suka sami manyan allurai na UVR na rayuwa sune suka fi sauƙi, kamar kai, wuya, ƙirji, da goshi. NMSC ana iya magance shi cikin sauri idan an gano shi da wuri.
Ciwon daji na fata da UVB Phototherapy
Yayin da UVB ke da alhakin kona fata (erythema) da NMSC, yana da wuyar gaske kuma igiyar igiyar ruwa ce ke yin Vitamin D a cikin fata kuma shine mafi inganci don maganin cututtukan fata da yawa.

Don rage erythema da NMSC yayin da har yanzu ke ba da ingantaccen maganin cututtukan fata, UVB-Narrowband (311nm peak, /01) Philips Lighting ya haɓaka shi a cikin 1980s kuma yanzu ya mamaye hoto na likita a duk duniya. Don ƙarin bayani duba: Fahimtar Narrowband UVB Phototherapy.

Melanoma ita ce cutar kansar fata mafi haɗari saboda tana iya yada kansa zuwa sauran sassan jiki. “Wataƙila haɗuwar abubuwa da suka haɗa da yanayin muhalli da kuma kwayoyin halitta, suna haifar da melanoma. Har yanzu, likitoci sun yi imanin kamuwa da cutar ultraviolet (UV) daga rana da kuma fitulun tanning da gadaje shi ne babban dalilin cutar melanoma.17

Hasken UV baya haifar da duk melanomas, musamman waɗanda ke faruwa a wurare a jikinka waɗanda basu sami hasken rana ba. Wannan yana nuna cewa wasu dalilai na iya taimakawa ga haɗarin melanoma. Melanoma na iya haifar da duka UVA da UVB, amma akwai wasu shaidun cewa UVA na iya taka muhimmiyar rawa.3

Abubuwan haɗari na Melanoma sun haɗa da: moles (melanocytic nevi), nau'in fata (masu fata masu fata suna cikin haɗari fiye da waɗanda suke da fata masu duhu), da maimaita kunar rana, musamman a lokacin ƙuruciya. "Bayyanar ɗan lokaci zuwa tsananin hasken rana yana da alaƙa da haɓakar melanoma fiye da ci gaba da fitowar rana ta yau da kullun. " 6

Amma duk da haka za a bayyana gaskiyar cewa "Melanoma ya fi yawa a tsakanin mutanen da ke da sana'a na cikin gida fiye da mutanen da ke samun tarin abubuwan UV masu yawa (manoma, masunta, da dai sauransu)."

Yawancin wallafe-wallafen kimiyya na ciwon daji na fata suna da alaƙa da tasirin hasken rana (UVR, wanda ya ƙunshi mafi yawan UVA, tare da raguwar kashi na UVB yayin da latitude ya karu),

Amma menene game da lokacin da ake amfani da UVB kawai (tare da cire UVA), kamar yadda a cikin likita UVB / UVB-Narrowband phototherapy?

Duk da cewa aikin bakan na NMSC ya kusan gaba ɗaya a cikin kewayon UVB, binciken da ke sama ya nuna cewa UVB/UVB-Narrowband phototherapy ba shine babban haɗari ga ciwon daji na fata ba; ciki har da basal cell carcinoma (BCC), squamous cell carcinoma (SCC) da kuma cutar m melanoma (CMM).

Rashin yiwuwar UVA mai cutarwa yana iya taka rawa, kuma "Gabaɗaya, akwai wasu shaidun cewa bitamin D na iya taka rawa a cikin cututtukan fata marasa lafiya (NMSC) da rigakafin melanoma, kodayake har yanzu babu wata shaida ta kai tsaye don nuna tasirin kariya." 14,15 "Yawancin karatu sun nuna cewa bitamin D yana taka rawar kariya a cikin nau'ikan malignancies na ciki. Game da ciwon daji na fata, nazarin cututtukan cututtuka da na dakin gwaje-gwaje sun nuna cewa bitamin D da metabolites na iya samun irin wannan tasirin kariya.. " 13

Don magance damuwa tare da UVB da aka jawo NMSC, saboda yana dogara ne akan adadin adadin rayuwa na rayuwa, musamman ga masu fata masu fata, yana da hankali don ware daga jiyya wuraren fata waɗanda ba sa buƙatar magani kuma sun sami UVR mai yawa a cikin rayuwar mai haƙuri. da kuma kare waɗannan wuraren daga ƙarin UVR daga hasken rana na halitta. Wadanda ke da tarihi da/ko tarihin iyali na ciwon fata ya kamata su tuntubi likitan su kafin daukar hoto na UV. Ya kamata su kuma yi "dubawar fata" a kalla kowace shekara don gano ciwon daji; kamar yadda ya kamata duk wanda ya fallasa hasken ultraviolet, ya kasance daga likitancin hoto na UV, kayan tanning na kwaskwarima, ko hasken rana na halitta.

Bugu da ƙari kuma, UVR daga hasken rana na halitta yawanci ana karɓa daga sama da mutum (misali rana tana haskakawa daga sama akan goshi, kunnuwa da kafadu), yayin da cikakken jiki UVB phototherapy kusan ana isar da shi daga gefe (masu jinya yawanci suna tsayawa don magani daga na'urar da aka ɗora a tsaye), don haka akwai raguwar ɗaukar hoto zuwa mafi haɗarin wuraren fata. Lokaci na farko na "sharewa" na UVB yawanci ya ƙunshi ƙara yawan allurai UVB phototherapy a cikin watanni da yawa, tare da dogon lokaci "tsara" jiyya a rage allurai da mita.

Cikakkun Jiki rana
Cikakken Na'urar Jiki
UVB phototherapy baya buƙatar mai haƙuri ya sami kunar rana, kuma allurai na UVB ƙasa da matsakaicin suna da tasiri don kulawa na dogon lokaci.Shin Raka'o'in Gida na kunkuntar Ultraviolet B zaɓi ne mai yuwuwa don Ci gaba ko Kulawa da Cututtukan fata masu ɗaukar hoto?” ,18 da kuma kula da isasshen bitamin D. 09,11,12

Duk na'urorin SolRx UVB-Narrowband suna bin Kiwon Lafiyar Kanada don "Rashin Vitamin-D" azaman "alama don amfani", wanda ke nufin an ƙaddara su zama lafiya da inganci, don haka ana iya siyar da su ta doka don wannan dalili a Kanada. 10

Game da Gida phototherapy, tsari mai ban sha'awa na shan jiyya da yanayin ɗan adam yana jagorantar majiyyaci don ɗaukar adadin UVB kawai don kula da fata mai haske ko kusan bayyananne. Marasa lafiyar hoto na gida yawanci sun zama ƙwararru kan adadin UVB da za su ɗauka da lokacin, tare da ƙarami, yawancin allurai da yawa suna fifita su.

Phototherapy na gida kuma yana sa ba a rasa jiyya ba kuma jiyya na gaba suna haifar da kunar rana da ba a so. Ku sani, "Ultraviolet B phototherapy a gida yana daidai da tasiri don kula da psoriasis a matsayin ultraviolet B phototherapy a cikin wurin jinya kuma yana nuna babu ƙarin haɗarin aminci a cikin yanayin da zai hana yiwuwar bayyanar cututtuka. Bugu da ƙari kuma, maganin gida yana haifar da ƙananan nauyi, an fi godiya da shi, kuma yana ba da irin wannan cigaba a cikin ingancin rayuwa. Yawancin marasa lafiyar sun ce za su fi son maganin ultraviolet B a nan gaba a gida akan maganin hoto a cikin wurin jinya. " 16

Solarc Systems na maraba da duk wani shawarwari don inganta wannan labarin bayanan jama'a.

NOTE

Yana da mahimmanci cewa UVB da UVB-Narrowband phototherapy ba su da rudani da PUVA (psoralen + UVA haske), kamar yadda "an nuna rawar da PUVA far a cikin fata carcinogenesis a cikin mutane tare da psoriasis a fili" [Hadarin ciwon daji na PUVA da nbUVB a cikin plaque na psoriasis na yau da kullun_ bita na wallafe-wallafen 2012] PUVA don haka galibi ana iyakance shi ga jiyya 200 zuwa 300, kuma kawai ga mafi tsanani lokuta da suka kasa UVB ko UVB-Narrowband phototherapy.   

References:

1 Brenner, Michaela, da Vincent J. Ji. "Matsayin Kariya na Melanin Daga Lalacewar UV a Fatar Dan Adam. " Photochemistry da Photobiology, vol. 84, ba. 3, 2007, shafi 539-549., doi:10.1111/j.1751-1097.2007.00226.x.

2 "Ciwon daji na fata / Cibiyar Melanoma: Alamu, Jiyya, Alamomi, Nau'o'i, Dalilai, da Gwaje-gwaje. WebMD

3 Setlow, RB, et al. "Tsawon Tsayin Tasirin Induction na Malignant Melanoma.Aikace-aikace na National Academy of Sciences, vol. 90, ba. 14, 1993, shafi 6666–6670., doi:10.1073/pnas.90.14.6666.

4 Berneburg, Mark, da Lena Krieger. "Bangaren 1000 Evaluation for Melanoma Induction by Ultraviolet A amma Ba Ultraviolet B Radiation Yana Bukatar Melanin Pigment." F1000 - Binciken Abokan Zamani Bayan Bugawa na Adabin Halittu, 2012, doi:10.3410/f.717952967.793458514.

5 Brenner, Michaela, da Vincent J. Ji. "Matsayin Kariya na Melanin Daga Lalacewar UV a Fatar Dan Adam. " Photochemistry da Photobiology, vol. 84, ba. 3, 2007, shafi 539-549., doi:10.1111/j.1751-1097.2007.00226.x.

6 Rhodes, A.Abubuwan Haɗarin Melanoma. " AIM a Melanoma, Fitzpatrick's Dermatology in General Medicine

7 Juzeniene, Asta, da Johan Moan. "Tasirin Amfanin UV Radiation Banda ta hanyar Samar da Vitamin D. " Dermato-Endocrinology, vol. 4, ba. 2, 2012, shafi 109-117., doi:10.4161/derm.20013.

8 Maverakis, Emanual, et al. "Haske, Ciki har da Ultraviolet. " Cibiyar Lafiya ta kasa, Mayu 2010, doi:10.1016/j.jaut.2009.11.011.

9 Amurka, Majalisa, Shirin Kiwon Lafiya na Ƙasa. "Broad-Spectrum Ultraviolet (UV) Radiation da UVA, da UVB, da UVC.Broad-Spectrum Ultraviolet (UV) Radiation da UVA, da UVB, da UVC, Kamfanin Tsare-tsaren Fasaha da Gudanarwa, 2000.

10 "Bayanin Tsarin Mulki." Solarc Systems Inc. girma,

11 Bogh, Mkb, et al. "Narrowband Ultraviolet B Sau Uku a kowane mako Yafi Inganci wajen Magance Rashin Vitamin D fiye da 1600IU Vitamin D3 na baka a kowace Rana: Gwajin Nazari na asibiti.. " Jaridar Burtaniya ta ilimin likitanci, vol. 167, ba. 3, 2012, shafi 625-630., doi:10.1111/j.1365-2133.2012.11069.x.

12 Ala-Houhala, Mj, et al. "Kwatanta Ƙwararren Ƙwararren Ƙwararren Ƙwararren Ƙwararren Ƙwararren Ƙwararren Ƙwararren Ƙwararren Ƙwararren Ƙwararren Ƙwararren Ƙwararren Ƙwararren Ƙwararren Ƙwararren Ƙwararren Ƙwararren Ƙwararren Ƙwararren Ƙwararren Ƙwararren Ƙwararren Ƙwararren Ƙwararren Ƙwararren Ƙwararren Ƙwararren Ƙwararren Ƙwararren Ƙwararren Ƙwararren Ƙwararren Ƙwararren Ƙwararren Ƙwararren Ƙwararren Ƙwararren Ƙwararren Ƙwararren Ƙwararren Ƙwaƙwalwa na Ƙaƙwalwa na Ƙaƙwalwa na Ƙaƙwalwa na 25 ) ya yi.Jaridar Burtaniya ta ilimin likitanci, vol. 167, ba. 1, 2012, shafi 160–164., doi:10.1111/j.1365-2133.2012.10990.x

13 Tang, Jean Y., et al. "Vitamin D a cikin Cutaneous Carcinogenesis: Sashe na I.Cibiyar Lafiya ta kasa, Nuwamba 2012, doi:10.1016/j.jaad.2012.05.044.

14 Tang, Jean Y., et al. "Vitamin D a cikin Cutaneous Carcinogenesis: Sashe na II.Cibiyar Lafiya ta kasa, Nuwamba 2012, doi:10.1016/j.jaad.2012.05.044.

15 Navarrete-Dechent, Cristián, et al. "Kewayawa Bitamin-D Protein Daure da Kyautar 25-Hydroxyvitamin D Mahimmanci a cikin Marasa lafiya tare da Melanoma: Nazarin Sarrafa Harka."Journal of the American Academy of Dermatology, vol. 77, ba. 3, 2017, shafi 575-577., doi:10.1016/j.jaad.2017.03.035.

16 Koek, M. BG, et al. "Gida da na Mara lafiya na Ƙwararren Ƙwararren Ƙwararren Ƙwararren Ƙwararren Ƙwararren Ƙwararren Ƙwararren Ƙwararren Ƙwararren Ƙwararren Ƙwararrun Ƙwararrun Ƙwararrun Ƙwararrun Ƙwararrun Ƙwararrun Ƙwararrun Ƙwararrun Ƙwararrun Ƙwararrun Ƙwararrun Ƙwararrun Ƙwararrun Ƙwararrun Ƙwararrun Ƙwararrun Ƙwararrun Ƙwararrun Ƙwararrun Ƙwararrun Ƙwararru (Nazarin PLUTO)." Bmj, vol. 338, ba. mayu 07, Yuli 2, doi:2009/bmj.b10.1136.

17 https://www.mayoclinic.org/diseases-conditions/melanoma/symptoms-causes/syc-20374884

18 Shin Raka'o'in Gida na kunkuntar Ultraviolet B zaɓi ne mai yuwuwa don Ci gaba ko Kulawa da Cututtukan fata masu ɗaukar hoto?"